We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. Charlene Hunter is a developer and an incredible advocate for increasing diversity in tech. Survival of Late Pleistocene hunter-gatherer ancestry in the Iberian Peninsula. We tested the affinity of Tutkaul 1 to worldwide ancient and modern populations relative to AG3. 27, 32023208.e9 (2017). Cold Spring Harb. You need more data until you have the right ingredients to make a good recipe, but you also need less data until you have the right amount of ingredients to make a bad recipe. Madrid, Madrid, Spain. Philos. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. The pairwise f2 distance matrix of Epigravettian-associated groups was generated with qpfstats 200 in ADMIXTOOLS 7.0.2 package, with parameters allsnps: YES, scale: NO, and Mbuti.DG set as the outgroup. Ancient admixture in human history. Its like the different ingredients in your recipe. Moreover, two of the oldest published groups from western Russia belonging to the Sidelkino clusterPeschanitsa (13ka)43 and the newly reported Minino individuals (11ka)showed extra affinity to the Oberkassel cluster, possibly owing to variability in this ancestry proportion during the initial formation phase of the Sidelkino-ancestry profile. I am attending the Future of Data and AI by Data Science Dojo on March 1st and 2nd, 2023. My name is Tina and I'm a data scientist and YouTuber. H. Rougier and I.C. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. Curr. R Programming in Data Science: High Variety Data SQL Server . Tina: Creates YouTube videos with millions of views on data science careers, learning to code, SQL, productivity, and study techniques. It was awesome seeing the thought process behind each of the questions - it helps students immensely! Moreover, the Oberkassel cluster carries both Villabruna ancestry and a contribution from GoyetQ2 ancestry (Supplementary Data 2.J). a, The genetic ancestry of hunter-gatherers dated between 14ka and 5.2ka modelled using qpAdm, with Oberkassel, Yuzhniy Oleniy Ostrov, Goyet Q-2 and Neolithic farmers from present-day Turkey (Barcn, Mentee and Boncuklu sites) representing Oberkassel (WHG) (blue), Sidelkino (EHG) (red), GoyetQ2 (orange) and Anatolian Neolithic farmer (green) ancestries, respectively. b, Gravettian-associated individuals form two distinct groups, with central-eastern and southern European individuals as part of the Vstonice cluster and western and southwestern European individuals as part of the Fournol cluster. To mark the occasion, rather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. This project has received funding by the European Research Council under the European Unions Horizon 2020 research and innovation programme under grant agreements no. This course will help you build a deliberate strategy when participating in a data scientist job interview involving SQL. They were different in many aspects, including their skin and eye colour," says He Yu. Dr. Huang received her BS degree in Chemistry from Bethel College and her PhD in Analytical Chemistry from the University of Kansas in 1998. Modern humans have populated Europe for more than 45,000 years1,2. Between 14 and 8ka, all hunter-gatherers in western and central Europe carried only Oberkassel ancestry, with no detectable contribution from the Sidelkino cluster. Previous studies have shown that two main hunter-gatherer ancestries were predominant across most parts of Europe after around 14kathat is, the western hunter-gatherer (WHG) ancestry, related to the Villabruna cluster, and the eastern hunter-gatherer (EHG) ancestry, showing affinity to both the Villabruna and the ancient north Eurasian (ANE) ancestry found in Upper Palaeolithic Siberian individuals4,36. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers, https://doi.org/10.1038/s41586-023-05726-0. Lipson, M. et al. Therefore, contrary to previous suggestions34, this demonstrates that the post-LGM diffusion of the Magdalenian was indeed associated with northward and northeastward population expansions from western Europe35. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers. We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). We further tested whether individuals included in the Vstonice and Fournol clusters share similar allele frequencies with the main representatives of those two clusters. Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. Genome Biol. This may have prompted people from the south to expand their habitat. You probably remember me from class or an event, and that's why this profile is so interesting - it traces my journey from student-athlete at the University of California Davis into a successful entrepreneur with multiple ventures under her belt by age 25, Your email address will not be published. 15, 22792300 (2020). Metadata information of studied individuals. Tina Huang. TV Actress. I'm I've learned SQL before, but I need a refresher. 1925). After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Think about some of your favorite apps today: Instagram, Uber, Facebook, and YouTube. The colours correspond to the grouping of tested populations, dots refer to the f4-values and the dark and light error bars to 1*SE and 3*SE estimated from 5 cM block jackknife, respectively. Genetics 192, 10651093 (2012). Commun. As previously hinted37, we find a large frequency variation in alleles related to skin and eye pigmentation among post-LGM hunter-gatherer groups. The length of each coloured bar represents the fraction of individuals carrying the corresponding haplogroup (legend on the right of each panel). Catalano, G. et al. Natl Acad. Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. Extensive farming in Estonia started through a sex-biased migration from the steppe. c, MDS plot of European hunter-gatherers based on 1f3(Mbuti; pop1, pop2). Tina Huang, a former engineer at Apple, Google, and Twitter, explains why she started API management startup Transposit. We looked at data on how many people had been dropped, the time when they were dropped, and the time they were found. @hellotinah. Are you Tina Huang? Dotted lines delimit geographic regions described in the text. Los Angeles, California, United States. Some of those early groups from more than 40ka further admixed with Neanderthals, as shown by signals of recent introgression in individuals from Bacho Kiro in Bulgariaassociated with an Initial Upper Palaeolithic (IUP) archaeological cultureand from Petera cu Oase in Romania2,6. Details of the modelling are provided in Supplementary Data 3.C. I help students become independent data scientists who are not just good at data analysis, but are also able to think about their own learning and the world around them. How to Become a Data Scientist at FAANG (Ft. Tina Huang) In this video, I had the opportunity to talk with Tina Huang, a Data Scientist at one of the FAANG companies. ISSN 1476-4687 (online) Tina Huang, a data scientist currently working at a FAANG (Facebook, Amazon, Apple, Netflix, and Google Alphabet) company. Ecol. Highly recommended for not only people preparing for interviews but for people that just want to improve their coding skills. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). The Gravettian from a palaeodemographic point of view. Otte, M.) 105160 (Errance, 2013). Google Scholar. From AI YouTubers to accessibilityadvocates. Ringbauer, H., Novembre, J. 2a). Where it all started :) I make weekly videos about self learning, practical productivity, and coding. Tina Huang is a recent graduate of Stanford. Li, H. & Durbin, R. Fast and accurate short read alignment with BurrowsWheeler transform. Graduate - February 2015 to September 2015. Amina is a software engineer, who is also an accessibility advocate and content creator. Total students. Paradis, E., Claude, J. The Villabruna ancestry later appeared in central Europe and it is thought to have largely replaced groups related to the GoyetQ2ancestry4. 255, 106796 (2021). Moreover, the almost complete genetic replacement of the Magdalenian-associated gene pool raises the hypothesis that parts of Europe were differentially populated during the abrupt climatic variation starting around 14.7ka with the BllingAllerd warming period, creating areas where southern European populations could expand. PubMed 4a). The MySQL engine is also known for being extremely slow compared to others. As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. Tina Huang I'm a data scientist, youtuber, and the first Lonely Octopus . In the first place, we have traditional analysis. Billed once. Palma di Cesnola, A. Mathieson, I. et al. Data science is a lot like cooking. Error bars show 1s.e.m. The labels in italic denote previously published individuals without new data generated in this study. Kotula, A., Piezonka, H. & Tergerger, T. The Mesolithic cemetery of Gro Fredenwalde (north-eastern Germany) and its cultural affiliations. Curr. In anticipation of possible near-term approval from the US Food and Drug Administration for renal denervation, there must be an insistence on longer-term clinical outcomes and safety data. Fab Business Solutionsis a ProfessionalNewsPlatform. The PCA was calculated with 1379 individuals from 87 western Eurasian modern populations on the 1240k_HO dataset, which was intersected between the 1240k and Human Origins datasets (Supplementary Data 1.K). Notably, the Fournol ancestry provides a better proxy than Goyet Q116-1 for the genetic component found in the GoyetQ2 cluster and in El Mirn (Supplementary Data 2.H). Kozowski, S. K., Potowicz-Bobak, M., Bobak, D. & Terberger, T. New information from Maszycka Cave and the Late Glacial recolonisation of Central Europe. The membrane was able to achieve FRR of 98.73 0.83 % after 4 cycles of filtration, indicating that anti-fouling properties have been enhanced. Quat. Cambridge Archaeol. Tina Huang Data Scientist. under exclusive license to Springer Nature Singapore Pte Ltd. 2022 R. Huang et al. Her first stepping stone into data science was being a research assistant in Bioinformatics. Posth, C., Yu, H., Ghalichi, A. et al. 19-78-10053). The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. Commun. a, MDS plot of pre-LGM individuals. Kristen Bell. Saag, L. et al. Hi, my name is Tina and I'm a data scientist at a FAANG company. Within Sicily, the 14ka Oriente C individual shows higher affinity with the much younger but geographically closer 10ka Uzzo group30 (n=2) than with the almost contemporaneous San Teodoro 2 individual from eastern Sicily. & Dolukhanov, P.) 122145 (Avebury, 1993). Overall, the literature suggests that Chinese Canadian students demonstrate high levels of achievement and that this academic success is associated with factors such as stronger feelings of ethnic identity, better English language skills in the family, Chinese . Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. A similar pattern is observed through the analysis of ROH segments (Extended Data Fig. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. The course is well structured and just what one needs before preparing for a data science interview with focus on SQL. I think its cool to see a project like this happen and I hope its interesting for people to learn more about how this stuff works. In no time, she established herself as one of the favorite vloggers of the data community. 2932 and Supplementary Table 4). Tina Huang is very empowering, and she knows what she is talking about. Freshwater radiocarbon reservoir effects at the burial ground of Minino, Northwest Russia. Biol. Lifetime access to all course materials and updates. In other cases, you may have to create a more complex database structure (such as SQLite). Sikora, M. et al. El Mirn has a significantly higher similarity to theVillabruna clusterthan Fournol 85 and Le Piage II, while the affinity to theVillabruna cluster in Le Piage II is not significantly higher than in Fournol 85 (Supplementary Data 2.D). The key areas to focus on when getting started in data science [6:01] Tina's five steps to consistently doing anything [11:55] Tina's day-to-day life as a data scientist at one of the world's largest tech companies [20:02] How Tina's computer science background helps her work [26:20] Traditional banking culture vs big tech [32:12] In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. 29, 11691177.e7 (2019). mtDNA capture63 was also performed for those libraries where mtDNA coverage was not high enough to assess mtDNA haplogroup and contamination. Protoc. Get the most important science stories of the day, free in your inbox. Biol. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. Have any problems using the site? Sci. Meyer, M. & Kircher, M. Illumina sequencing library preparation for highly multiplexed target capture and sequencing. This suggests that between the Early/Middle and Late Gravettian there was an east-to-west expansion of the Vstonice-associated ancestry that reached central-western Europe and created a longitudinal admixturecline between those two genetically distinct pre-LGM populations. Follow. The genetic affinity to the Villabruna ancestry is present in El Mirn and in Magdalenian-associated individuals from western and central Europe. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. My experience includes an internship at Goldman Sachs where I did some machine learning work before I took up my current data science job in tech. Within the pipeline, the adapters were removed by AdapterRemoval 2.2.065, reads were mapped with BWA 0.7.12 aln/samse algorithm66, duplications were removed by DeDup 0.12.1 (https://github.com/apeltzer/DeDup) and damage patterns of each library were checked with mapDamage 2.0.6 and 2.0.967. In her journey of eventually. Kozowski, J. K. The origin of the Gravettian. c, Admixture graph modelling of the main pre-LGM European hunter-gatherer lineages created using qpGraph. Here is a sampling of five herbs that have demonstrated potential immune support benefits: 1. Lifetime access to all course materials and updates. 27, 18011810.e10 (2017). 272273, 354361 (2012). Second, the ancestry of individuals associated with the Epigravettian culture (Villabruna cluster), which was found to genetically connect European and Near Eastern hunter-gatherers, reached southern Europe well before the transition between the Early and Late Epigravettian4,15 and possibly as early as the GravettianEpigravettian transition. On the basis of PCA and outgroup f3-statistics, the Neolithic Tutkaul 1 individual from Tajikistan is closely related to Upper Palaeolithic individuals from south-central Siberia (Afontova Gora 3 (AG3) and Malta 1), and roughly contemporaneous West Siberian hunter-gatherers (Tyumen and Sosnoviy), both carrying high proportions of ANE ancestry45 (Fig. Tina Huang. But she came up with a way to break down the code and create a website that she was proud of. The indexed products for each library were pooled, purified over MinElute columns (Qiagen), eluted in 50l TET and again quantified using the IS5 and IS6 primers59 using the quantification method described above. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. About me. DNA was extracted from the generated bone or tooth powder following established protocols. Danielle Fishel. A 5700 year-old human genome and oral microbiome from chewed birch pitch. This, together with the evidence of Villabruna ancestry in El Mirn 19ka, further suggests that this genetic discontinuity could be the result of palaeogeographic and palaeoecological transformations connected to the LGM32, rather than to the BllingAllerd warming period4,15 (14.712.9ka). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Powered by Symplectic part of Digital Science . 12, 5425 (2021). The triangles show the average calibrated dates of the tested groups and the dots show the estimated admixture dates with the software DATES105 using Oberkassel (red dots) or Villabruna (blue dots) clusters as one source and ANE-related individuals as the other source population. Much attention has b Fluorescent probes targeting specific organelles are useful tools for understanding their intracellular behaviors. No, there are no prerequisites for enrolling. 26, 827833 (2016). Shes the founder of Coding Black Females, a nonprofit with the aim to provide opportunities for Black female developers to develop themselves, meet familiar faces, network, receive support, and build relationships through having regular meetups., Check out the Coding Black Females website. van de Loosdrecht, M. et al. I worked in bioinformatics in cancer research and then decided to a masters in computer science (MCIT) from the University of . The human remains were processed in dedicated laboratories at the Max Planck Institute for the Science of Human History in Jena (Germany), University of Tbingen (Germany), University of Florence (Italy), Leiden University Medical Center (the Netherlands) and University of Tartu (Estonia). Notes 9, 88 (2016). PLoS ONE 14, e0217996 (2019). The incoming Villabruna ancestry later became the most widespread hunter-gatherer ancestry across Europe. Nature 536, 419424 (2016). Google Scholar. Connect with them: Email: hellotinah@gmail.com. Extended Data Fig. The x-axis shows the average age of each tested individual/group and the y-axis shows the proportion of Sidelkino ancestry, relative to the total hunter-gatherer ancestry (Oberkassel + Sidelkino) in each group. Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. Individuals with at least one library showing Y/Auto ratio > 0.2 were determined as maleindividuals, and with Y/Auto < 0.2 were determined as femaleindividuals4 (Supplementary Fig. Many students or recent graduates appreciate her for sharing what helped her break into the field. Taiwan. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. First, I like it because of how powerful (almost magical) it is in driving decisions. All individuals belonging to the Fournol cluster show higher affinity to Goyet Q116-1 than to the Sunghir group (n=4), and the Vstonice-cluster individuals show higher affinity to the Sunghir group than to Goyet Q116-1 (Extended Data Fig. On top of that, its full of useful career and productivity advice, so you can find out what knowledge you need to become a data scientist as well as how to break into the field. Her main topic is AI, exploring how it works and, most interestingly, how we increasingly interact with it in the world. All in the name of developing an amazing product! A negative and cave bear positive controls were included. Using f4-statistics and qpAdm, we confirm that EHG populations in eastern Europe are a mixture of Villabruna/Oberkassel and ANE ancestries (Supplementary Information, section11 and Supplementary Data 2.K). Echinacea, also known as Coneflower, is legendary for a reason: science has shown multiple species of Echinacea can provide potentially broad-reaching support for the innate and adaptive immune system. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in View Tina Zhang's business profile as Brand Specialist at Dymind Biotechnology. 16, 224 (2015). The compiled genotype file used for analyses, including re-genotyped published genomes, has been uploaded at the Edmond Data Repository of the Max Planck Society (https://edmond.mpdl.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.Y1KJMF). The bivariate plots show the expansion of Oberkassel and Sidelkino ancestries through time in two European areas (longitude below and above 30 degrees). Further palaeogenomic studies on Upper Palaeolithic individuals from the Balkans will be essential for understanding whether southeastern Europe represents the source of the Villabruna ancestry and a climatic refugium for human populations during the LGM. www.sciencedaily.com/releases/2023/03/230301120846.htm (accessed March 4, 2023). Therefore,most of the ancestry found in these post-LGM individuals probably traced back to Gravettian-associated groups from western and southwestern Europe. Slider with three articles shown per slide. Fu, Q. et al. This broadly distributed ancestry (the Oberkassel cluster (also known as WHG)) is most closely related to an Epigravettian-associated individual from northwestern Italy, suggesting that its expansion into continental Europe might have started from the westand not the eastside of the Alps. Dismiss. Sci. At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value. Shes currently at Microsoft. 27, 21852193.e6 (2017). Open access funding provided by Max Planck Society. Ideally, we also want lots of data because this will give us more confidence in our results. The deduplicated bam files were filtered using PMDtools 0.6068 with a threshold of 3, to reduce potential modern DNA contamination based on postmortem DNA deamination. National Science Council feb. 2009 - feb. 2009 1 maand. Science 338, 222226 (2012). Populations headed south? Taiwan Patent Application M401603, filed 11th April . Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. CAS Proc. Further information on research design is available in theNature Portfolio Reporting Summary linked to this article. The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. Tina Llorca CPA, CWP, CEPP, CIS, MDRT Expand search. The ancestry found in individuals associated with the preceding Aurignacian culture from central Europe (GoyetQ116-1ancestry) gave rise to Gravettian-associated individuals from western and southwestern Europe. She then served as a postdoctoral associate at the National Institute of Standards and Technology. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. Instead, in southern Europe, a distinct hunter-gatherer genetic profile was found as early as 17ka in individuals associated with the Epigravettian culture15 (2412ka, from the Italian peninsula to the southeastern European Plain across the Balkans). The phylogenetic reconstruction of Epigravettian-associated genomes, with Pradis 1 diverging more deeply than all others, indicates that the turnover took place much earlier than 17kathe date of the more derived Tagliente 2 genome. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. University Universit Chouaib Doukkali; . Patterson, N., Price, A. L. & Reich, D. Population structure and eigenanalysis. My experience includes an [] Ive always liked the idea of using data to make predictions. & Nielsen, R. ANGSD: analysis of next generation sequencing data. She has been working for the data sciences industry since 2014. Upper Palaeolithic genomes reveal deep roots of modern Eurasians. Adapted from https://doi.org/10.5281/zenodo.5903165 (CC BY 4.0). Learn in-demand skills with a structured course that prepares you for the world of data science as it is today.